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Your Position: Home > MIS RII

MIS RII

Brief Information

Name:Anti-Mullerian hormone receptor II
Target Synonym:Anti-Mullerian Hormone Receptor, Type II,AMHR2,MRII,AMH Type II Receptor,MISRII,Muellerian Inhibiting Substance Type II Receptor,MIS Type II Receptor,Anti-Muellerian hormone type-2 receptor,EC:2.7.11.30,Mullerian Inhibiting Substance Type II Receptor,MISR2,AMHR,Anti-Muellerian Hormone Type-2 Receptor,Anti-Mullerian Hormone Receptor Type 2,EC 2.7.11.30,Anti-Muellerian Hormone Type II Receptor,Anti-Mullerian Hormone Receptor Type II
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
MII-H5254 Human Human MIS RII Protein, Llama IgG2b Fc Tag, low endotoxin
MII-H5254-structure
MII-H5254-sds
MII-H5253 Human Human MIS RII Protein, Mouse IgG2a Fc Tag
MII-H5253-structure
MII-H5253-sds
MII-H82E3 Human Biotinylated Human MIS RII Protein, His,Avitag™
MII-H82E3-structure
MII-H82E3-sds
MII-M52H6 Mouse Mouse MIS RII Protein, His Tag
MII-M52H6-structure
MII-M52H6-sds
MII-H52H6 Human Human MIS RII Protein, His Tag
MII-H52H6-structure
MII-H52H6-sds
MII-C52H5 Cynomolgus Cynomolgus MIS RII Protein, His Tag
MII-C52H5-structure
MII-C52H5-sds
MII-H5258 Human Human MIS RII Protein, Fc Tag
MII-H5258-structure
MII-H5258-sds
ACRO Quality

Synonym Name

MIS RII,MRII,AMHR2,AMHR,MISR2,AMH type II receptor

Background

MIS RII (Mullerian inhibiting substance type II receptor), also known as AMHRII (anti-Mullerian hormone type II receptor), is a serine/threonine receptor with a single transmembrane domain that belongs to the family of type II receptors of the TGF-beta superfamily. Mutations in MIS RII result in persistent Mullerian duct syndrome (PMDS), persistent Müllerian duct syndrome (PMDS) is a sex-limited disorder in which males develop portions of the female reproductive tract. Anti-Müllerian hormone (AMH) and its receptor (AMHR2) induce the regression of the Müllerian ducts in male embryos, but the mechanism by which the Amhr2 gene is specifically activated is not fully understood.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Murlentamab 3C23-K; GM-102 Phase 2 Clinical Lfb Biotechnologies Sas Genital Neoplasms, Female; Colorectal Neoplasms Details

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